Gamma locator for radionuclide diagnostics of oncological diseases

Description:

Keywords

Nuclear medicine, radionuclide diagnostics, radioguided surgery, gamma-ray detector, gamma probe

 

Applications

Radionuclide diagnostics of oncological diseases, radioguided surgery, sentinel lymph nodes localization

 

Problem statement

According to the World Health Organization more than 7,5 million people die from cancer every year. In Russia at the beginning of 2011 more than 2,6 million patients were registered in oncological hospitals. Over the last 10 years the number of cancer patients in the country increased by 25.5%. Over the past 10 years, the number of cancer patients in the country increased by 25.5%. Most often, the probability of recovery from cancer is higher if pathological changes were diagnosed earlier. This requires highly accurate, efficient diagnostic tools, which are easy to use and safe for the patient. “Gamma-locator” is a device that meets all the listed requirements.

 

Technology

Gamma-locator is a miniature γ-ray detector used in nuclear medicine to determine spatial distribution of radiopharmaceuticals in a human body in the real time mode. Radiopharmaceuticals containing γ-active radionuclides (e.g., 99mTc-MIBI and 99mTc-tetrophosmine) rapidly absorbed by certain tumors are introduced in the patient’s blood vascular system. The technique of manual scanning with a miniature γ detector in the course of radionuclide diagnostics complements tomographic investigations using γ cameras and positron emission tomographs. Miniature γ-detectors are also used for the intraoperative localization of lymph nodes, affected with metastases.

Gamma-locator is based on a locally produced LaBr3:Ce inorganic scintillator, which exhibits a high efficiency for γ rays, and a silicon photomultiplier (SiPM), which features internal amplification of the optical signal. SiPM is packed together with a scintillator in a sealed duralumin enclosure. Readout electronics are mounted on a double sided PCB. Tungsten collimator with a wall thickness of 2 mm is used to narrow a field of view of the detector. Indication is performed by an acoustic signal and a digital display.

 

Advantages

Low cost in comparison with commercially available analogs

High sensitivity to medical radionuclides – 12 pps/kBq for 99m-Tc

Spatial resolution – 7 mm

Spatial selectivity – 26 degrees

Alternative application areas – quality control of radiopharmaceuticals, industrial radiation monitoring

 

Publications

A. Yagnyukova, T. Khabibullin, A. Bolozdynya, V. Kantserov, K. Zhukov “Gamma Probe Based on Scintillation Crystal and Silicon Photomultiplier”, Radiotherapy and oncology V110 Supplement 1-108, Elsevier 2014

A. K. Yagnyukova, A. I. Bolozdynya, K. A. Vorobiev, E. I. Evgrafova, K. I. Zhukov, V. A. Kantserov, V. V. Sosnovtsev, D. E. Filipov “A γ Probe for Radionuclide Diagnostics of Cancer”, Instruments and Experimental Techniques, 2015, Vol. 58, No. 1, pp. 153–157

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Gamma locator for radionuclide diagnostics of oncological diseases National Patent Application Russia RU 144697 3/26/2014    
For Information, Contact:
Sergey Ulyakhin
Licensing and Technology Transfer Manager
The Skolkovo Institute of Science and Technology
s.ulyakhin@skoltech.ru
Inventors:
Vladimir Belyaev
Alexander Bolozdynya
Anastasia Berdnikova
Valery Sosnovtsev
Vadim Kantserov
Keywords:
© 2017. All Rights Reserved. Powered by Inteum